Doctor Strange, actual named Stephen Vincent Strange, co-created by Jack Kirby and Stan Lee, first appearance in Strange Tales #110 in July 1963.

Stephen's origin story relates that he was once a brilliant but egotistical surgeon. After a car accident severely damages his hands and hinders his ability to perform surgery, he searches the globe for a way to repair them and encounters the Ancient One. After becoming one of the old Sorcerer Supreme's students, he becomes a practitioner of both the mystical arts as well as martial arts. Along with knowing many powerful spells, he has a costume with two mystical objects—the Cloak of Levitation and Eye of Agamotto—which give him added powers. Strange is aided along the way by his friend and valet, Wong, and a large assortment of mystical objects. He takes up residence in a mansion called the Sanctum Sanctorum, located in New York City. Later, Strange takes the title of Sorcerer Supreme, the primary protector of Earth against magical and mystical threats.

Inspired by stories of black magic and Chandu the Magician, Strange was created during the Silver Age of Comic Books to bring a different kind of character and themes of mysticism to Marvel Comics.

Steve conceived the idea for the character, wanting to add variety to the characters under Marvel. He was later named Doctor Strange because he would be making appearance in Strange Tales.

Doctor Strange is a practicing magician who draws his powers from mystical entities such as Agamotto, Cyttorak, Ikonn, Oshtur, Raggadorr, and Watoomb, who lend their energies for spells. Strange also wields mystical artifacts including the Cloak of Levitation which enables him to fly; the Eye of Agamotto, an amulet whose light is used to negate evil magic; the Book of the Vishanti, a grimoire which contains knowledge of white magic; and the Orb of Agamotto, a crystal ball which is used for clairvoyance.

In addition to his magical abilities, Strange is trained in several martial arts disciplines, and has shown proficiency with numerous magically conjured weapons including swords and axes. Strange was a skilled neurosurgeon before nerve damage impaired his hands.

Doctor Strange is described as "the mightiest magician in the cosmos" and "more powerful by far than any of your fellow humanoids" by Eternity, the sentience of the Marvel Universe. He holds the title of Sorcerer Supreme from 1973 (with the death of the Ancient One) to the present, except during an interruption from 1992 to 1995. He relinquishes the title once again in 2009, but reclaims it in 2012 when he proves himself willing to protect the world even without the title.